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Upregulation of Yy1 Suppresses Dilated Cardiomyopathy caused by Ttn insufficiency

Truncating variants in TTN (TTNtv), coding for the largest structural protein in the sarcomere, contribute to the largest portion of familial and ambulatory dilated cardiomyopathy (DCM). TTN haploinsufficiency caused by TTNtv is suggested as the disease mechanism. However, it is unclear whether TTN...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Liao, Dan, Chen, Weiming, Tan, Chia Yee, Wong, Jing Xuan, Chan, Pui Shi, Tan, Lek Wen, Foo, Roger, Jiang, Jianming
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6841687/
https://ncbi.nlm.nih.gov/pubmed/31705051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-52796-0
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