Set-up and screening of a fragment library targeting the 14-3-3 protein interface

Protein–protein interactions (PPIs) are at the core of regulation mechanisms in biological systems and consequently became an attractive target for therapeutic intervention. PPIs involving the adapter protein 14-3-3 are representative examples given the broad range of partner proteins forming a comp...

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Bibliographische Detailangaben
Veröffentlicht in:Medchemcomm
Hauptverfasser: Valenti, Dario, Neves, João Filipe, Cantrelle, François-Xavier, Hristeva, Stanimira, Lentini Santo, Domenico, Obšil, Tomáš, Hanoulle, Xavier, Levy, Laura M., Tzalis, Dimitrios, Landrieu, Isabelle, Ottmann, Christian
Format: Artigo
Sprache:Inglês
Veröffentlicht: Royal Society of Chemistry 2019
Schlagworte:
Chemistry
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6839876/
https://ncbi.nlm.nih.gov/pubmed/31814953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9md00215d
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