Progressive Polyglutamine Repeat Expansion in Peripheral Blood Cells and Sperm of Transgenic Huntington’s Disease Monkeys

The expanded CAG repeat results in somatic mosaicism and genetic anticipation in Huntington’s disease (HD). Here we report a longitudinal study examining CAG repeat instability in lymphocytes and sperm of three HD monkeys throughout their whole life-span that encompass the prodromal to symptomatic s...

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Bibliografiske detaljer
Udgivet i:J Huntingtons Dis
Main Authors: Clever, Faye, Cho, In Ki, Yang, Jingjing, Chan, Anthony W.S.
Format: Artigo
Sprog:Inglês
Udgivet: IOS Press 2019
Fag:
Research Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6839466/
https://ncbi.nlm.nih.gov/pubmed/31561381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JHD-190359
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