Higher matrix stiffness as an independent initiator triggers epithelial-mesenchymal transition and facilitates HCC metastasis

BACKGROUND: Increased liver stiffness exerts a detrimental role in driving hepatocellular carcinoma (HCC) malignancy and progression, and indicates a high risk of unfavorable outcomes. However, it remains largely unknown how liver matrix stiffness as an independent cue triggers epithelial-mesenchyma...

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Detalhes bibliográficos
Publicado no:J Hematol Oncol
Main Authors: Dong, Yinying, Zheng, Qiongdan, Wang, Zhiming, Lin, Xiahui, You, Yang, Wu, Sifan, Wang, Yaohui, Hu, Chao, Xie, Xiaoying, Chen, Jie, Gao, Dongmei, Zhao, Yan, Wu, Weizhong, Liu, Yinkun, Ren, Zhenggang, Chen, Rongxin, Cui, Jiefeng
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6839087/
https://ncbi.nlm.nih.gov/pubmed/31703598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-019-0795-5
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