Matrix stiffness-upregulated LOXL2 promotes fibronectin production, MMP9 and CXCL12 expression and BMDCs recruitment to assist pre-metastatic niche formation

BACKGROUND: Higher matrix stiffness affects biological behavior of tumor cells, regulates tumor-associated gene/miRNA expression and stemness characteristic, and contributes to tumor invasion and metastasis. However, the linkage between higher matrix stiffness and pre-metastatic niche in hepatocellu...

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Dades bibliogràfiques
Publicat a:J Exp Clin Cancer Res
Autors principals: Wu, Sifan, Zheng, Qiongdan, Xing, Xiaoxia, Dong, Yinying, Wang, Yaohui, You, Yang, Chen, Rongxin, Hu, Chao, Chen, Jie, Gao, Dongmei, Zhao, Yan, Wang, Zhiming, Xue, Tongchun, Ren, Zhenggang, Cui, Jiefeng
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2018
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5935912/
https://ncbi.nlm.nih.gov/pubmed/29728125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-018-0761-z
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