Higher Matrix Stiffness Upregulates Osteopontin Expression in Hepatocellular Carcinoma Cells Mediated by Integrin β1/GSK3β/β-Catenin Signaling Pathway

Increased stromal stiffness is associated with hepatocellular carcinoma (HCC) development and progression. However, the molecular mechanism by which matrix stiffness stimuli modulate HCC progress is largely unknown. In this study, we explored whether matrix stiffness-mediated effects on osteopontin...

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Udgivet i:PLoS One
Main Authors: You, Yang, Zheng, Qiongdan, Dong, Yinying, Wang, Yaohui, Zhang, Lan, Xue, Tongchun, Xie, Xiaoying, Hu, Chao, Wang, Zhiming, Chen, Rongxin, Wang, Yanhong, Cui, Jiefeng, Ren, Zhenggang
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4539226/
https://ncbi.nlm.nih.gov/pubmed/26280346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0134243
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