Engineering of a Lectibody Targeting High-Mannose-Type Glycans of the HIV Envelope

High-mannose-type glycans (HMGs) are aberrantly enriched on HIV envelope glycoproteins. However, there is currently no drug selectively targeting HIV-associated HMGs. Here, we describe a novel HMG-targeting “lectibody,” a recombinant Fc-fusion protein comprising human IgG1 Fc and a novel actinohivin...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Hamorsky, Krystal Teasley, Kouokam, J. Calvin, Dent, Matthew W., Grooms, Tiffany N., Husk, Adam S., Hume, Steven D., Rogers, Kenneth A., Villinger, Francois, Morris, Mary Kate, Hanson, Carl V., Matoba, Nobuyuki
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2019
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6839005/
https://ncbi.nlm.nih.gov/pubmed/31471224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2019.07.021
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