Efficient Single Tobamoviral Vector-Based Bioproduction of Broadly Neutralizing Anti-HIV-1 Monoclonal Antibody VRC01 in Nicotiana benthamiana Plants and Utility of VRC01 in Combination Microbicides

Broadly neutralizing monoclonal antibodies (bnMAbs) may offer powerful tools for HIV-1 preexposure prophylaxis, such as topical microbicides. However, this option is hampered due to expensive MAb biomanufacturing based on mammalian cell culture. To address this issue, we developed a new production s...

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Dettagli Bibliografici
Autori principali: Hamorsky, Krystal Teasley, Grooms-Williams, Tiffany W., Husk, Adam S., Bennett, Lauren J., Palmer, Kenneth E., Matoba, Nobuyuki
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2013
Soggetti:
Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3632893/
https://ncbi.nlm.nih.gov/pubmed/23403432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02588-12
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