Engineering of a Lectibody Targeting High-Mannose-Type Glycans of the HIV Envelope

High-mannose-type glycans (HMGs) are aberrantly enriched on HIV envelope glycoproteins. However, there is currently no drug selectively targeting HIV-associated HMGs. Here, we describe a novel HMG-targeting “lectibody,” a recombinant Fc-fusion protein comprising human IgG1 Fc and a novel actinohivin...

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Publicat a:Mol Ther
Autors principals: Hamorsky, Krystal Teasley, Kouokam, J. Calvin, Dent, Matthew W., Grooms, Tiffany N., Husk, Adam S., Hume, Steven D., Rogers, Kenneth A., Villinger, Francois, Morris, Mary Kate, Hanson, Carl V., Matoba, Nobuyuki
Format: Artigo
Idioma:Inglês
Publicat: American Society of Gene & Cell Therapy 2019
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6839005/
https://ncbi.nlm.nih.gov/pubmed/31471224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2019.07.021
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