Apelin-36-[L28A] and Apelin-36-[L28C(30kDa-PEG)] peptides that improve diet induced obesity are G protein biased ligands at the apelin receptor

BACKGROUND: Apelin signalling pathways have important cardiovascular and metabolic functions. Recently, apelin-36-[L28A] and apelin-36-[L28C(30kDa-PEG)], were reported to function independent of the apelin receptor in vivo to produce beneficial metabolic effects without modulating blood pressure. We...

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Publicado en:Peptides
Main Authors: Nyimanu, Duuamene, Kuc, Rhoda E., Williams, Thomas L., Bednarek, Maria, Ambery, Philip, Jermutus, Lutz, Maguire, Janet J., Davenport, Anthony P.
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier Science Inc 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6838674/
https://ncbi.nlm.nih.gov/pubmed/31472173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.peptides.2019.170139
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