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Application of a genome-scale model in tandem with enzyme assays for identification of metabolic signatures of high and low CHO cell producers
Biopharmaceutical industrial processes are based on high yielding stable recombinant Chinese Hamster Ovary (CHO) cells that express monoclonal antibodies. However, the process and feeding regimes need to be adapted for each new cell line, as they all have a slightly different metabolism and product...
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| Publicado en: | Metab Eng Commun |
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| Autores principales: | , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Elsevier
2019
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6838488/ https://ncbi.nlm.nih.gov/pubmed/31720213 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mec.2019.e00097 |
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