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Application of a genome-scale model in tandem with enzyme assays for identification of metabolic signatures of high and low CHO cell producers

Biopharmaceutical industrial processes are based on high yielding stable recombinant Chinese Hamster Ovary (CHO) cells that express monoclonal antibodies. However, the process and feeding regimes need to be adapted for each new cell line, as they all have a slightly different metabolism and product...

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Detalhes bibliográficos
Publicado no:Metab Eng Commun
Main Authors: Calmels, Cyrielle, Arnoult, Solène, Ben Yahia, Bassem, Malphettes, Laetitia, Andersen, Mikael Rørdam
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6838488/
https://ncbi.nlm.nih.gov/pubmed/31720213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mec.2019.e00097
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