FoxO1-mediated inhibition of STAT1 alleviates tubulointerstitial fibrosis and tubule apoptosis in diabetic kidney disease

BACKGROUND: Tubulointerstitial fibrosis (TIF) plays an important role in the progression of diabetic kidney disease (DKD). Forkhead box O1 (FoxO1) is involved in the regulation of metabolism and cell apoptosis, but its function in renal TIF induced by DKD is less well understood. METHODS: Human kidn...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Huang, Fengjuan, Wang, Qingzhu, Guo, Feng, Zhao, Yanyan, Ji, Linlin, An, Tingting, Song, Yi, Liu, Yang, He, Yanyan, Qin, Guijun
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
Research paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6838438/
https://ncbi.nlm.nih.gov/pubmed/31629675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.09.002
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