Protein lysine 43 methylation by EZH1 promotes AML1-ETO transcriptional repression in leukemia

The oncogenic fusion protein AML1-ETO retains the ability of AML1 to interact with the enhancer core DNA sequences, but blocks AML1-dependent transcription. Previous studies have shown that post-translational modification of AML1-ETO may play a role in its regulation. Here we report that AML1-ETO-po...

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Udgivet i:Nat Commun
Main Authors: Dou, Liping, Yan, Fei, Pang, Jiuxia, Zheng, Dehua, Li, Dandan, Gao, Li, Wang, Lijun, Xu, Yihan, Shi, Jinlong, Wang, Qian, Zhou, Lei, Shen, Na, Singh, Puja, Wang, Lili, Li, Yonghui, Gao, Yvchi, Liu, Tao, Chen, Chongjian, Al-Kali, Aref, Litzow, Mark R., Chi, Young-In, Bode, Ann M., Liu, Chunhui, Huang, Haojie, Liu, Daihong, Marcucci, Guido, Liu, Shujun, Yu, Li
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6838331/
https://ncbi.nlm.nih.gov/pubmed/31699991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12960-6
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