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Inactivation of receptor tyrosine kinases reverts aberrant DNA methylation in acute myeloid leukemia

PURPOSE: Receptor tyrosine kinases (RTKs) are frequently deregulated in leukemia, yet the biological consequences of this deregulation remain elusive. The mechanisms underlying aberrant methylation, a hallmark of leukemia, are not fully understood. Here we investigated the role of RTKs in methylatio...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Shen, Na, Yan, Fei, Pang, Jiuxia, Zhao, Na, Gangat, Naseema, Wu, Laichu, Bode, Ann M., Al-Kali, Aref, Litzow, Mark R., Liu, Shujun
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5641248/
https://ncbi.nlm.nih.gov/pubmed/28720666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-0235
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