A suicide inhibitor of nematode trehalose-6-phosphate phosphatases

Protein-based drug discovery strategies have the distinct advantage of providing insights into the molecular mechanisms of chemical effectors. Currently, there are no known trehalose-6-phosphate phosphatase (TPP) inhibitors that possess reasonable inhibition constants and chemical scaffolds amenable...

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Publicado en:Sci Rep
Main Authors: Cross, Megan, York, Mark, Długosz, Ewa, Straub, Jan Hendrik, Biberacher, Sonja, Herath, H. M. P. Dilrukshi, Logan, Stephanie A., Kim, Jeong-Sun, Gasser, Robin B., Ryan, John H., Hofmann, Andreas
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6838324/
https://ncbi.nlm.nih.gov/pubmed/31700060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-52593-9
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