Collagenase Nanoparticles Enhance the Penetration of Drugs into Pancreatic Tumors

Overexpressed extracellular matrix (ECM) in pancreatic ductal adenocarcinoma (PDAC) limits drug penetration into the tumor and is associated with poor prognosis. Here, we demonstrate that a pretreatment based on a proteolytic-enzyme nanoparticle system, disassembles the dense PDAC collagen stroma, a...

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izdano v:ACS Nano
Main Authors: Zinger, Assaf, Koren, Lilach, Adir, Omer, Poley, Maria, Alyan, Mohammed, Yaari, Zvi, Noor, Nadav, Krinsky, Nitzan, Simon, Assaf, Gibori, Hadas, Krayem, Majd, Mumblat, Yelena, Kasten, Shira, Ofir, Sivan, Fridman, Eran, Milman, Neta, Lübtow, Michael M., Liba, Lior, Shklover, Jeny, Shainsky-Roitman, Janna, Binenbaum, Yoav, Hershkovitz, Dov, Gil, Ziv, Dvir, Tal, Luxenhofer, Robert, Satchi-Fainaro, Ronit, Schroeder, Avi
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6837877/
https://ncbi.nlm.nih.gov/pubmed/31503443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsnano.9b02395
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