Collagenase Nanoparticles Enhance the Penetration of Drugs into Pancreatic Tumors

Overexpressed extracellular matrix (ECM) in pancreatic ductal adenocarcinoma (PDAC) limits drug penetration into the tumor and is associated with poor prognosis. Here, we demonstrate that a pretreatment based on a proteolytic-enzyme nanoparticle system, disassembles the dense PDAC collagen stroma, a...

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Veröffentlicht in:ACS Nano
Hauptverfasser: Zinger, Assaf, Koren, Lilach, Adir, Omer, Poley, Maria, Alyan, Mohammed, Yaari, Zvi, Noor, Nadav, Krinsky, Nitzan, Simon, Assaf, Gibori, Hadas, Krayem, Majd, Mumblat, Yelena, Kasten, Shira, Ofir, Sivan, Fridman, Eran, Milman, Neta, Lübtow, Michael M., Liba, Lior, Shklover, Jeny, Shainsky-Roitman, Janna, Binenbaum, Yoav, Hershkovitz, Dov, Gil, Ziv, Dvir, Tal, Luxenhofer, Robert, Satchi-Fainaro, Ronit, Schroeder, Avi
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6837877/
https://ncbi.nlm.nih.gov/pubmed/31503443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsnano.9b02395
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