Collagenase Nanoparticles Enhance the Penetration of Drugs into Pancreatic Tumors

Overexpressed extracellular matrix (ECM) in pancreatic ductal adenocarcinoma (PDAC) limits drug penetration into the tumor and is associated with poor prognosis. Here, we demonstrate that a pretreatment based on a proteolytic-enzyme nanoparticle system, disassembles the dense PDAC collagen stroma, a...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:ACS Nano
Main Authors: Zinger, Assaf, Koren, Lilach, Adir, Omer, Poley, Maria, Alyan, Mohammed, Yaari, Zvi, Noor, Nadav, Krinsky, Nitzan, Simon, Assaf, Gibori, Hadas, Krayem, Majd, Mumblat, Yelena, Kasten, Shira, Ofir, Sivan, Fridman, Eran, Milman, Neta, Lübtow, Michael M., Liba, Lior, Shklover, Jeny, Shainsky-Roitman, Janna, Binenbaum, Yoav, Hershkovitz, Dov, Gil, Ziv, Dvir, Tal, Luxenhofer, Robert, Satchi-Fainaro, Ronit, Schroeder, Avi
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6837877/
https://ncbi.nlm.nih.gov/pubmed/31503443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsnano.9b02395
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker