Collagenase Nanoparticles Enhance the Penetration of Drugs into Pancreatic Tumors

Overexpressed extracellular matrix (ECM) in pancreatic ductal adenocarcinoma (PDAC) limits drug penetration into the tumor and is associated with poor prognosis. Here, we demonstrate that a pretreatment based on a proteolytic-enzyme nanoparticle system, disassembles the dense PDAC collagen stroma, a...

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Detalhes bibliográficos
Publicado no:ACS Nano
Main Authors: Zinger, Assaf, Koren, Lilach, Adir, Omer, Poley, Maria, Alyan, Mohammed, Yaari, Zvi, Noor, Nadav, Krinsky, Nitzan, Simon, Assaf, Gibori, Hadas, Krayem, Majd, Mumblat, Yelena, Kasten, Shira, Ofir, Sivan, Fridman, Eran, Milman, Neta, Lübtow, Michael M., Liba, Lior, Shklover, Jeny, Shainsky-Roitman, Janna, Binenbaum, Yoav, Hershkovitz, Dov, Gil, Ziv, Dvir, Tal, Luxenhofer, Robert, Satchi-Fainaro, Ronit, Schroeder, Avi
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6837877/
https://ncbi.nlm.nih.gov/pubmed/31503443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsnano.9b02395
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