Collagenase Nanoparticles Enhance the Penetration of Drugs into Pancreatic Tumors

Overexpressed extracellular matrix (ECM) in pancreatic ductal adenocarcinoma (PDAC) limits drug penetration into the tumor and is associated with poor prognosis. Here, we demonstrate that a pretreatment based on a proteolytic-enzyme nanoparticle system, disassembles the dense PDAC collagen stroma, a...

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Detaylı Bibliyografya
Yayımlandı:ACS Nano
Asıl Yazarlar: Zinger, Assaf, Koren, Lilach, Adir, Omer, Poley, Maria, Alyan, Mohammed, Yaari, Zvi, Noor, Nadav, Krinsky, Nitzan, Simon, Assaf, Gibori, Hadas, Krayem, Majd, Mumblat, Yelena, Kasten, Shira, Ofir, Sivan, Fridman, Eran, Milman, Neta, Lübtow, Michael M., Liba, Lior, Shklover, Jeny, Shainsky-Roitman, Janna, Binenbaum, Yoav, Hershkovitz, Dov, Gil, Ziv, Dvir, Tal, Luxenhofer, Robert, Satchi-Fainaro, Ronit, Schroeder, Avi
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6837877/
https://ncbi.nlm.nih.gov/pubmed/31503443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsnano.9b02395
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