USP18 is a significant driver of memory CD4 T-cell reduced viability caused by type I IFN signaling during primary HIV-1 infection

The loss of Memory CD4 T-cells (Mem) is a major hallmark of HIV-1 immuno-pathogenesis and occurs early during the first months of primary infection. A lot of effort has been put into understanding the molecular mechanisms behind this loss, yet they still have not been fully identified. In this study...

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Bibliographic Details
Published in:PLoS Pathog
Main Authors: Dagenais-Lussier, Xavier, Loucif, Hamza, Cadorel, Hugo, Blumberger, Juliette, Isnard, Stéphane, Bego, Mariana Gé, Cohen, Éric A., Routy, Jean-Pierre, van Grevenynghe, Julien
Format: Artigo
Language:Inglês
Published: Public Library of Science 2019
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6837632/
https://ncbi.nlm.nih.gov/pubmed/31658294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008060
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