Kynurenine Reduces Memory CD4 T-Cell Survival by Interfering with Interleukin-2 Signaling Early during HIV-1 Infection

Early HIV-1 infection is characterized by enhanced tryptophan catabolism, which contributes to immune suppression and disease progression. However, the mechanism by which kynurenine, a tryptophan-related metabolite, induces immune suppression remains poorly understood. Herein, we show that the incre...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Virol
Prif Awduron: Dagenais-Lussier, Xavier, Aounallah, Mouna, Mehraj, Vikram, El-Far, Mohamed, Tremblay, Cecile, Sekaly, Rafick-Pierre, Routy, Jean-Pierre, van Grevenynghe, Julien
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2016
Pynciau:
Pathogenesis and Immunity
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4988137/
https://ncbi.nlm.nih.gov/pubmed/27356894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00994-16
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg