Kynurenine Reduces Memory CD4 T-Cell Survival by Interfering with Interleukin-2 Signaling Early during HIV-1 Infection

Early HIV-1 infection is characterized by enhanced tryptophan catabolism, which contributes to immune suppression and disease progression. However, the mechanism by which kynurenine, a tryptophan-related metabolite, induces immune suppression remains poorly understood. Herein, we show that the incre...

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Bibliographic Details
Published in:J Virol
Main Authors: Dagenais-Lussier, Xavier, Aounallah, Mouna, Mehraj, Vikram, El-Far, Mohamed, Tremblay, Cecile, Sekaly, Rafick-Pierre, Routy, Jean-Pierre, van Grevenynghe, Julien
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2016
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4988137/
https://ncbi.nlm.nih.gov/pubmed/27356894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00994-16
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