Tyr(740) and Tyr(751) residues of platelet-derived growth factor beta receptor are responsible for the redox regulation of phosphatase and tensin homolog in the cells stimulated with platelet-derived growth factor

Exposure of cells to hydrogen peroxide or platelet-derived growth factor (PDGF) induced Akt phosphorylation and oxidation of phosphatase and tensin homolog (PTEN). The Cys(124) and Cys(71) residues of PTEN were critical for the formation of a disulfide bond and the intermediate glutathionylation in...

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Detalles Bibliográficos
Publicado en:Redox Rep
Main Authors: Kim, Inyoung, Han, Seong-Jeong, Kim, Yujeong, Ahn, Younghee, Chay, Kee-Oh, Lee, Seung-Rock
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 2013
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6837401/
https://ncbi.nlm.nih.gov/pubmed/21888769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1179/1351000211Y.0000000005
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