Development of benzochalcone derivatives as selective CYP1B1 inhibitors and anticancer agents

A series of benzochalcone derivatives have been synthesized and evaluated for CYP1 inhibitory activity and cytotoxic properties against wild type cell lines (MCF-7 and MDA-MB-231) and drug resistant cell lines (LCC6/P-gp and MCF-7/1B1). All of these compounds were found to have selective inhibition...

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Bibliografiske detaljer
Udgivet i:Medchemcomm
Main Authors: Dong, Jinyun, Huang, Guang, Zhang, Qijing, Wang, Zengtao, Cui, Jiahua, Wu, Yan, Meng, Qingqing, Li, Shaoshun
Format: Artigo
Sprog:Inglês
Udgivet: Royal Society of Chemistry 2019
Fag:
Chemistry
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6837174/
https://ncbi.nlm.nih.gov/pubmed/31803401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9md00258h
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