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Differential toxicity of ataxin-3 isoforms in Drosophila models of Spinocerebellar Ataxia Type 3
The most commonly inherited dominant ataxia, Spinocerebellar Ataxia Type 3 (SCA3), is caused by a CAG repeat expansion that encodes an abnormally long polyglutamine (polyQ) repeat in the disease protein ataxin-3, a deubiquitinase. Two major full-length isoforms of ataxin-3 exist, both of which conta...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Neurobiol Dis |
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| Κύριοι συγγραφείς: | , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2019
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6834911/ https://ncbi.nlm.nih.gov/pubmed/31310802 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2019.104535 |
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