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Polyglutamine length-dependent toxicity from α1ACT in Drosophila models of spinocerebellar ataxia type 6
Spinocerebellar ataxia type 6 (SCA6) is a neurodegenerative disease that results from abnormal expansion of a polyglutamine (polyQ) repeat. SCA6 is caused by CAG triplet repeat expansion in the gene CACNA1A, resulting in a polyQ tract of 19-33 in patients. CACNA1A, a bicistronic gene, encodes the α1...
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| Publicado no: | Biol Open |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Company of Biologists Ltd
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5200913/ https://ncbi.nlm.nih.gov/pubmed/27979829 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.021667 |
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