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Beneficial effects of PGC-1α in the substantia nigra of a mouse model of MPTP-induced dopaminergic neurotoxicity

Background: Mitochondrial dysfunction and oxidative stress are closely associated with the pathogenesis of Parkinson’s disease. Peroxisome proliferator-activated receptor γ coactivator 1 alpha (PGC-1α) is thought to play multiple roles in the regulation of mitochondrial biogenesis and cellular energ...

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Dades bibliogràfiques
Publicat a:Aging (Albany NY)
Autors principals: Wang, Yingqing, Chen, Chun, Huang, Wanling, Huang, Maoxin, Wang, Juhua, Chen, Xiaochun, Ye, Qinyong
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6834419/
https://ncbi.nlm.nih.gov/pubmed/31634150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.102357
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