Heat shock factor 1-mediated transcription activation of Omi/HtrA2 induces myocardial mitochondrial apoptosis in the aging heart

Background: Increased cardiac apoptosis is a hallmark of the elderly, which in turn increases the risk for developing cardiac disease. The overexpression of Omi/HtrA2 mRNA and protein contributes to apoptosis in the aged heart. Heat shock factor 1 (HSF1) is a transcription factor that binds to the p...

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Bibliografiske detaljer
Udgivet i:Aging (Albany NY)
Main Authors: Liu, Dan, Wu, Linguo, Wu, Ye, Wei, Xin, Wang, Wen, Zhang, Suli, Yi, Ming, Li, Jing, Liu, Huirong, Ma, Xinliang
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals 2019
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6834417/
https://ncbi.nlm.nih.gov/pubmed/31627188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.102361
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