Cardiac Specific Overexpression of Mitochondrial Omi/HtrA2 Induces Myocardial Apoptosis and Cardiac Dysfunction

Myocardial apoptosis is a significant problem underlying ischemic heart disease. We previously reported significantly elevated expression of cytoplasmic Omi/HtrA2, triggers cardiomyocytes apoptosis. However, whether increased Omi/HtrA2 within mitochondria itself influences myocardial survival in viv...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Wang, Ke, Yuan, Yuexing, Liu, Xin, Lau, Wayne Bond, Zuo, Lin, Wang, Xiaoliang, Ma, Lu, Jiao, Kun, Shang, Jianyu, Wang, Wen, Ma, Xinliang, Liu, Huirong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5141441/
https://ncbi.nlm.nih.gov/pubmed/27924873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep37927
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