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Toward the computational design of protein crystals with improved resolution

Substantial advances have been made in the computational design of protein interfaces over the last 20 years. However, the interfaces targeted by design have typically been stable and high-affinity. Here, we report the development of a generic computational design method to stabilize the weak intera...

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Veröffentlicht in:Acta Crystallogr D Struct Biol
Hauptverfasser: Jeliazkov, Jeliazko R., Robinson, Aaron C., García-Moreno E., Bertrand, Berger, James M., Gray, Jeffrey J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: International Union of Crystallography 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6834074/
https://ncbi.nlm.nih.gov/pubmed/31692475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2059798319013226
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