A conserved arginine/lysine-based motif promotes ER export of KCNE1 and KCNE2 to regulate KCNQ1 channel activity

KCNE β-subunits play critical roles in modulating cardiac voltage-gated potassium channels. Among them, KCNE1 associates with KCNQ1 channel to confer a slow-activated I(Ks) current, while KCNE2 functions as a dominant negative modulator to suppress the current amplitude of KCNQ1. Any anomaly in thes...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Channels (Austin)
Hauptverfasser: Hu, Bin, Zeng, Wen-Ping, Li, Xia, Al-Sheikh, Umar, Chen, San-You, Ding, Jiuping
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2019
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6833972/
https://ncbi.nlm.nih.gov/pubmed/31679457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19336950.2019.1685626
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