Landscape of Tumor Mutation Load, Mismatch Repair Deficiency, and PD-L1 Expression in a Large Patient Cohort of Gastrointestinal Cancers

The efficacy of immunotherapy varies widely among different gastrointestinal cancers. Response to immune checkpoint inhibitors is shown to correlate with tumor mutation load (TML), mismatch repair deficiency (dMMR) status, and programmed cell death-ligand 1 (PD-L1) expression. Herein, we quantify TM...

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Dettagli Bibliografici
Pubblicato in:Mol Cancer Res
Autori principali: Salem, Mohamed E., Puccini, Alberto, Grothey, Axel, Raghavan, Derek, Goldberg, Richard M., Xiu, Joanne, Korn, W. Michael, Weinberg, Benjamin A., Hwang, Jimmy J., Shields, Anthony F., Marshall, John L., Philip, Philip A., Lenz, Heinz-Josef
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6833953/
https://ncbi.nlm.nih.gov/pubmed/29523759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-17-0735
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