Landscape of Tumor Mutation Load, Mismatch Repair Deficiency, and PD-L1 Expression in a Large Patient Cohort of Gastrointestinal Cancers

The efficacy of immunotherapy varies widely among different gastrointestinal cancers. Response to immune checkpoint inhibitors is shown to correlate with tumor mutation load (TML), mismatch repair deficiency (dMMR) status, and programmed cell death-ligand 1 (PD-L1) expression. Herein, we quantify TM...

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Detalhes bibliográficos
Publicado no:Mol Cancer Res
Main Authors: Salem, Mohamed E., Puccini, Alberto, Grothey, Axel, Raghavan, Derek, Goldberg, Richard M., Xiu, Joanne, Korn, W. Michael, Weinberg, Benjamin A., Hwang, Jimmy J., Shields, Anthony F., Marshall, John L., Philip, Philip A., Lenz, Heinz-Josef
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6833953/
https://ncbi.nlm.nih.gov/pubmed/29523759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-17-0735
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