Evaluation of Cyclic Peptide Inhibitors of the Grb7 Breast Cancer Target: Small Change in Cargo Results in Large Change in Cellular Activity

Grb7 is an adapter protein, overexpressed in HER2+ve breast and other cancers, and identified as a therapeutic target. Grb7 promotes both proliferative and migratory cellular pathways through interaction of its SH2 domain with upstream binding partners including HER2, SHC, and FAK. Here we present t...

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Publicado no:Molecules
Main Authors: Sang, Jianrong, Kulkarni, Ketav, Watson, Gabrielle M., Ma, Xiuquan, Craik, David J., Henriques, Sónia T., Poth, Aaron G., Benfield, Aurélie H., Wilce, Jacqueline A.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6832895/
https://ncbi.nlm.nih.gov/pubmed/31627265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24203739
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