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Elevated glycolytic metabolism limits the formation of memory CD8+ T cells in early life

Neonates often develop poor immunity against intracellular pathogens. Since CD8+ T cells are essential for eliminating infectious agents, it is crucial to understand why they behave differently in early life. Previous studies in mice have demonstrated that neonatal CD8+ T cells fail to form memory b...

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Библиографические подробности
Опубликовано в: :J Immunol
Главные авторы: Tabilas, Cybelle, Wang, Jocelyn, Liu, Xiaojing, Locasale, Jason W., Smith, Norah L., Rudd, Brian D.
Формат: Artigo
Язык:Inglês
Опубликовано: 2019
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6832862/
https://ncbi.nlm.nih.gov/pubmed/31597706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1900426
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