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Rapid proliferation and differentiation impairs the development of memory CD8+ T cells in early life

Neonates often generate incomplete immunity against intracellular pathogens, although the mechanism of this defect is poorly understood. An important question is whether the impaired development of memory CD8+ T cells in neonates is due to an immature priming environment or lymphocyte-intrinsic defe...

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Detalhes bibliográficos
Main Authors: Smith, Norah L., Wissink, Erin, Wang, Jocelyn, Pinello, Jennifer F., Davenport, Miles P., Grimson, Andrew, Rudd, Brian D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4065808/
https://ncbi.nlm.nih.gov/pubmed/24850719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1400553
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