Rat Na(V)1.7 loss-of-function genetic model: Deficient nociceptive and neuropathic pain behavior with retained olfactory function and intra-epidermal nerve fibers

Recapitulating human disease pathophysiology using genetic animal models is a powerful approach to enable mechanistic understanding of genotype–phenotype relationships for drug development. Na(V)1.7 is a sodium channel expressed in the peripheral nervous system with strong human genetic validation a...

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Enregistré dans:
Détails bibliographiques
Publié dans:Mol Pain
Auteurs principaux: Grubinska, B, Chen, L, Alsaloum, M, Rampal, N, Matson, DJ, Yang, C, Taborn, K, Zhang, M, Youngblood, B, Liu, D, Galbreath, E, Allred, S, Lepherd, M, Ferrando, R, Kornecook, TJ, Lehto, SG, Waxman, SG, Moyer, BD, Dib-Hajj, S, Gingras, J
Format: Artigo
Langue:Inglês
Publié: SAGE Publications 2019
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6831982/
https://ncbi.nlm.nih.gov/pubmed/31550995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1744806919881846
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