Serum response factor (SRF) promotes ROS generation and hepatic stellate cell activation by epigenetically stimulating NCF1/2 transcription

Activation of hepatic stellate cells (HSC) is a hallmark event in liver fibrosis. Accumulation of reactive oxygen species (ROS) serves as a driving force for HSC activation. The regulatory subunits of the NOX complex, NCF1 (p47(phox)) and NCF2 (p67(phox)), are up-regulated during HSC activation cont...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Redox Biol
Hlavní autoři: Kong, Ming, Chen, Xuyang, Lv, Fangqiao, Ren, Haozhen, Fan, Zhiwen, Qin, Hao, Yu, Liming, Shi, Xiaolei, Xu, Yong
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2019
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6831835/
https://ncbi.nlm.nih.gov/pubmed/31442911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2019.101302
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky