Serum response factor (SRF) promotes ROS generation and hepatic stellate cell activation by epigenetically stimulating NCF1/2 transcription

Activation of hepatic stellate cells (HSC) is a hallmark event in liver fibrosis. Accumulation of reactive oxygen species (ROS) serves as a driving force for HSC activation. The regulatory subunits of the NOX complex, NCF1 (p47(phox)) and NCF2 (p67(phox)), are up-regulated during HSC activation cont...

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Udgivet i:Redox Biol
Main Authors: Kong, Ming, Chen, Xuyang, Lv, Fangqiao, Ren, Haozhen, Fan, Zhiwen, Qin, Hao, Yu, Liming, Shi, Xiaolei, Xu, Yong
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2019
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6831835/
https://ncbi.nlm.nih.gov/pubmed/31442911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2019.101302
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