Aldehyde dehydrogenase 1A1 confers erlotinib resistance via facilitating the reactive oxygen species-reactive carbonyl species metabolic pathway in lung adenocarcinomas

Background: Acquired resistance to epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) such as erlotinib is a major challenge to achieve an overall clinical benefit of the targeted therapy. Recently, aldehyde dehydrogenase 1 (ALDH1) induction has been found to render lung adeno...

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Detalhes bibliográficos
Publicado no:Theranostics
Main Authors: Lei, Hui-Min, Zhang, Ke-Ren, Wang, Cong Hui, Wang, Yang, Zhuang, Guang-Lei, Lu, Li-Ming, Zhang, Jian, Shen, Ying, Chen, Hong-Zhuan, Zhu, Liang
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2019
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Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6831290/
https://ncbi.nlm.nih.gov/pubmed/31695757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.35729
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