Aldehyde dehydrogenase 2 activation in aged heart improves the autophagy by reducing the carbonyl modification on SIRT1

Cardiac aging is characterized by accumulation of damaged proteins and decline of autophagic efficiency. Here, by forestalling SIRT1 carbonylated inactivation in aged heart, we determined the benefits of activation of aldehyde dehydrogenase 2 (ALDH2) on the autophagy. In this study, the ALDH2 KO mic...

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Publicat a:Oncotarget
Autors principals: Wu, Bing, Yu, Lu, Wang, Yishi, Wang, Hongtao, Li, Chen, Yin, Yue, Yang, Jingrun, Wang, Zhifa, Zheng, Qiangsun, Ma, Heng
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2016
Matèries:
Research Paper: Gerotarget (Focus on Aging)
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4823027/
https://ncbi.nlm.nih.gov/pubmed/26741505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6814
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