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Pharmacological Npt2a Inhibition Causes Phosphaturia and Reduces Plasma Phosphate in Mice with Normal and Reduced Kidney Function

BACKGROUND: The kidneys play an important role in phosphate homeostasis. Patients with CKD develop hyperphosphatemia in the later stages of the disease. Currently, treatment options are limited to dietary phosphate restriction and oral phosphate binders. The sodium-phosphate cotransporter Npt2a, whi...

詳細記述

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書誌詳細
出版年:J Am Soc Nephrol
主要な著者: Thomas, Linto, Xue, Jianxiang, Murali, Sathish Kumar, Fenton, Robert A., Dominguez Rieg, Jessica A., Rieg, Timo
フォーマット: Artigo
言語:Inglês
出版事項: American Society of Nephrology 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6830793/
https://ncbi.nlm.nih.gov/pubmed/31409727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2018121250
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