Opposing Functions of Interferon Coordinate Adaptive and Innate Immune Responses to Cancer Immune Checkpoint Blockade

Interferon-gamma (IFNG) augments immune function yet promotes T cell exhaustion through PDL1. How these opposing effects are integrated to impact immune checkpoint blockade (ICB) is unclear. We show that while inhibiting tumor IFNG signaling decreases interferon-stimulated genes (ISGs) in cancer cel...

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Pubblicato in:Cell
Autori principali: Benci, Joseph L., Johnson, Lexus R., Choa, Ruth, Xu, Yuanming, Qiu, Jingya, Zhou, Zilu, Xu, Bihui, Ye, Darwin, Nathanson, Katherine L., June, Carl H., Wherry, E. John, Zhang, Nancy R., Ishwaran, Hemant, Hellmann, Matthew D., Wolchok, Jedd D., Kambayashi, Taku, Minn, Andy J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6830508/
https://ncbi.nlm.nih.gov/pubmed/31398344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.07.019
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