Opposing Functions of Interferon Coordinate Adaptive and Innate Immune Responses to Cancer Immune Checkpoint Blockade

Interferon-gamma (IFNG) augments immune function yet promotes T cell exhaustion through PDL1. How these opposing effects are integrated to impact immune checkpoint blockade (ICB) is unclear. We show that while inhibiting tumor IFNG signaling decreases interferon-stimulated genes (ISGs) in cancer cel...

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Publicat a:Cell
Autors principals: Benci, Joseph L., Johnson, Lexus R., Choa, Ruth, Xu, Yuanming, Qiu, Jingya, Zhou, Zilu, Xu, Bihui, Ye, Darwin, Nathanson, Katherine L., June, Carl H., Wherry, E. John, Zhang, Nancy R., Ishwaran, Hemant, Hellmann, Matthew D., Wolchok, Jedd D., Kambayashi, Taku, Minn, Andy J.
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6830508/
https://ncbi.nlm.nih.gov/pubmed/31398344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.07.019
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