Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockade

Therapeutic blocking of the PD1 pathway results in significant tumor responses but resistance is common. We demonstrate that prolonged interferon signaling orchestrates PDL1-dependent and PDL1-independent resistance to immune checkpoint blockade (ICB), and to combinations such as radiation plus anti...

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Publicado no:Cell
Main Authors: Benci, Joseph L., Xu, Bihui, Qiu, Yu, Wu, Tony, Dada, Hannah, Victor, Christina Twyman-Saint, Cucolo, Lisa, Lee, David S.M., Pauken, Kristen E., Huang, Alexander C., Gangadhar, Tara C., Amaravadi, Ravi K., Schuchter, Lynn M., Feldman, Michael D., Ishwaran, Hemant, Vonderheide, Robert H., Maity, Amit, Wherry, E. John, Minn, Andy J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5385895/
https://ncbi.nlm.nih.gov/pubmed/27912061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.11.022
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