Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockade

Therapeutic blocking of the PD1 pathway results in significant tumor responses but resistance is common. We demonstrate that prolonged interferon signaling orchestrates PDL1-dependent and PDL1-independent resistance to immune checkpoint blockade (ICB), and to combinations such as radiation plus anti...

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Bibliografski detalji
Izdano u:Cell
Glavni autori: Benci, Joseph L., Xu, Bihui, Qiu, Yu, Wu, Tony, Dada, Hannah, Victor, Christina Twyman-Saint, Cucolo, Lisa, Lee, David S.M., Pauken, Kristen E., Huang, Alexander C., Gangadhar, Tara C., Amaravadi, Ravi K., Schuchter, Lynn M., Feldman, Michael D., Ishwaran, Hemant, Vonderheide, Robert H., Maity, Amit, Wherry, E. John, Minn, Andy J.
Format: Artigo
Jezik:Inglês
Izdano: 2016
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5385895/
https://ncbi.nlm.nih.gov/pubmed/27912061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.11.022
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