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The PI(4)P phosphatase Sac2 controls insulin granule docking and release
Insulin granule biogenesis involves transport to, and stable docking at, the plasma membrane before priming and fusion. Defects in this pathway result in impaired insulin secretion and are a hallmark of type 2 diabetes. We now show that the phosphatidylinositol 4-phosphate phosphatase Sac2 localizes...
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| Gepubliceerd in: | J Cell Biol |
|---|---|
| Hoofdauteurs: | , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Rockefeller University Press
2019
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6829663/ https://ncbi.nlm.nih.gov/pubmed/31533953 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201903121 |
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