The PI(4)P phosphatase Sac2 controls insulin granule docking and release

Insulin granule biogenesis involves transport to, and stable docking at, the plasma membrane before priming and fusion. Defects in this pathway result in impaired insulin secretion and are a hallmark of type 2 diabetes. We now show that the phosphatidylinositol 4-phosphate phosphatase Sac2 localizes...

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Detalles Bibliográficos
Publicado en:J Cell Biol
Main Authors: Nguyen, Phuoc My, Gandasi, Nikhil R., Xie, Beichen, Sugahara, Sari, Xu, Yingke, Idevall-Hagren, Olof
Formato: Artigo
Idioma:Inglês
Publicado: Rockefeller University Press 2019
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Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6829663/
https://ncbi.nlm.nih.gov/pubmed/31533953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201903121
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