Spontaneous Development of Dental Dysplasia in Aged Parp-1 Knockout Mice

Poly(ADP-ribose) polymerase (Parp)-1 catalyzes polyADP-ribosylation using NAD(+) and is involved in the DNA damage response, genome stability, and transcription. In this study, we demonstrated that aged Parp-1(−/−) mouse incisors showed more frequent dental dysplasia in both ICR/129Sv mixed backgrou...

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Bibliografske podrobnosti
izdano v:Cells
Main Authors: Fujihara, Hisako, Nozaki, Tadashige, Tsutsumi, Masahiro, Isumi, Mayu, Shimoda, Shinji, Hamada, Yoshiki, Masutani, Mitsuko
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6829344/
https://ncbi.nlm.nih.gov/pubmed/31569682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells8101157
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