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Adaptation to mutational inactivation of an essential gene converges to an accessible suboptimal fitness peak

The mechanisms of adaptation to inactivation of essential genes remain unknown. Here we inactivate E. coli dihydrofolate reductase (DHFR) by introducing D27G,N,F chromosomal mutations in a key catalytic residue with subsequent adaptation by an automated serial transfer protocol. The partial reversal...

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Bibliografiske detaljer
Udgivet i:eLife
Main Authors: Rodrigues, João V, Shakhnovich, Eugene I
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6828540/
https://ncbi.nlm.nih.gov/pubmed/31573512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.50509
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