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Adaptation to mutational inactivation of an essential gene converges to an accessible suboptimal fitness peak

The mechanisms of adaptation to inactivation of essential genes remain unknown. Here we inactivate E. coli dihydrofolate reductase (DHFR) by introducing D27G,N,F chromosomal mutations in a key catalytic residue with subsequent adaptation by an automated serial transfer protocol. The partial reversal...

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Détails bibliographiques
Publié dans:eLife
Auteurs principaux: Rodrigues, João V, Shakhnovich, Eugene I
Format: Artigo
Langue:Inglês
Publié: eLife Sciences Publications, Ltd 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6828540/
https://ncbi.nlm.nih.gov/pubmed/31573512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.50509
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