Deficiency of the autophagy gene ATG16L1 induces insulin resistance through KLHL9/KLHL13/CUL3-mediated IRS1 degradation

Connections between deficient autophagy and insulin resistance have emerged, however, the mechanism through which reduced autophagy impairs insulin-signaling remains unknown. We examined mouse embryonic fibroblasts lacking Atg16l1 (ATG16L1 KO mouse embryonic fibroblasts (MEFs)), an essential autopha...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Frendo-Cumbo, Scott, Jaldin-Fincati, Javier R., Coyaud, Etienne, Laurent, Estelle M. N., Townsend, Logan K., Tan, Joel M. J., Xavier, Ramnik J., Pillon, Nicolas J., Raught, Brian, Wright, David C., Brumell, John Hunter, Klip, Amira
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6827317/
https://ncbi.nlm.nih.gov/pubmed/31515271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009110
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