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Unexpected roles for ADH1 and SORD in catalyzing the final step of erythritol biosynthesis

The low-calorie sweetener erythritol is endogenously produced from glucose through the pentose phosphate pathway in humans. Erythritol is of medical interest because elevated plasma levels of this polyol are predictive for visceral adiposity gain and development of type 2 diabetes. However, the mech...

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Pubblicato in:J Biol Chem
Autori principali: Schlicker, Lisa, Szebenyi, Doletha M. E., Ortiz, Semira R., Heinz, Alexander, Hiller, Karsten, Field, Martha S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6827307/
https://ncbi.nlm.nih.gov/pubmed/31511322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009049
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