Identification of Celastrol as a Novel YAP-TEAD Inhibitor for Cancer Therapy by High Throughput Screening with Ultrasensitive YAP/TAZ–TEAD Biosensors

The Hippo pathway has emerged as a key signaling pathway that regulates a broad range of biological functions, and dysregulation of the Hippo pathway is a feature of a variety of cancers. Given this, some have suggested that disrupting the interaction of the Hippo core component YAP and its paralog...

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Bibliographic Details
Published in:Cancers (Basel)
Main Authors: Nouri, Kazem, Azad, Taha, Ling, Min, van Rensburg, Helena J. Janse, Pipchuk, Alexander, Shen, He, Hao, Yawei, Zhang, Jianmin, Yang, Xiaolong
Format: Artigo
Language:Inglês
Published: MDPI 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6826516/
https://ncbi.nlm.nih.gov/pubmed/31635084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11101596
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